From: Tom Grove [TGrove@careside.com] Sent: Thursday, January 11, 2001 9:26 AM To: John Lebihan Cc: Vick Stoughton Subject: H-2000 Reagent Formulation John, I have just concluded a patent search on hematology reagents (lyze, diluent, detergent flush, etc.) from 1976 to 2000. I am beginning to review the literature now. I have several questions for you to help me assess our position. 1. What is the origin of the TIL formulations? 2. Was it original work or copied/modified? 3. If original, do we have signed and dated research notebooks documenting the "discovery" of the formulations? 4. If they were copied/modified, then from whom? 5. If copied/modified, were the original formulations pre-1983? 6. Did TIL have permission/license? 7. If not, was an infringement review done? Please provide me with a copy of the references you used to come up with the present formulations being produced by Aqua Solutions. Tom